nswd



drugs

By bronze, by gold, in oceangreen of shadow

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Federal authorities have arrested eight men accused of distributing more than $1 million worth of LSD, ecstasy, and other narcotics with an online storefront that used the TOR anonymity service to mask their Internet addresses.

“The Farmer’s Market,” as the online store was called, was like an Amazon for consumers of controlled substances, according to a 66-page indictment unsealed on Monday. It offered online forums, Web-based order forms, customer service, and at least four methods of payment, including PayPal and Western Union. From January 2007 to October 2009, it processed some 5,256 orders valued at $1.04 million. The site catered to about 3,000 customers in 35 countries, including the United States.

To elude law enforcement officers, the operators used software provided by the TOR Project that makes it virtually impossible to track the activities of users’ IP addresses.

{ Ars Technica | Continue reading }

photos { Claes Källarsson | 1 | 2 }

‘Tout pouvoir a besoin de la tristesse.’ –Deleuze

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Weill wasn’t the first or the last Wall Streeter to deal with the pressures of high finance through the performance-enhancing highs of cocaine or with plenty of other stimulants. Just six years earlier, one of the Street’s best-known, self-made stars, Wardell Lazard, the head of his own investment firm, died naked and alone in a Pittsburgh hotel from an overdose of vodka and cocaine, just two weeks before his 45th birthday. (…)

A University of Southern California researcher, who was once herself a Wall Street banker, followed more than two dozen freshly minted MBA’s from the boot camps, or “grind mills,” of investment banks as they clawed their way toward wealth and absolute power. By the fourth year in business, they had succumbed to a litany of out-of-control behavior.

“People working 120 hours a week, for prolonged periods of time, go through harsh psychological transformations,” says Alexandra Michel, a professor at USC’s Marshall School of Business, who findings appear in the current Administrative Science Quarterly. (…)

Her research examines how organizations influence white-collar workers’ psychological processes and performance. She is particularly interested in the way knowledge-based workers—not just on Wall Street, but in the media, law, consulting, technology and countless other fields—perceive themselves as autonomous, but in fact they are under unspoken organizational control.

That control is veiled by the perqs offered to white collar workers. “The bank erased distinctions between work and leisure by providing administrative support 24 hours a day, seven days a week, encouraging leisure at work, and providing free amenities, including childcare, valets, car service, and meals,” Michel writes. “Some of the banks’ embodied controls focused on managing employees’ energy and included providing free caffeine and meals during ‘‘energy slumps,’’ hiring young people, focusing on energy as the main hiring criterion, and firing low performers because of their energy drain.”


As they became overtaxed, 80 percent of Michel’s workers said they were struggling to control their bodies. As one vice president put it: “I wouldn’t call it control; I am at war with my body.” They were also at war with their private lives. Michel saw highly educated and highly motivated people willing to miss a child’s birthday or cancel on parents visiting from overseas to instead help with a client’s hostile corporate takeover.


To cope, bankers developed addictions and compulsions, such as eating disorders, as well as embarrassing tics, such as nail biting, nose picking and hair twirling. Normally mild-mannered people flew into out-of-control rages at the least provocation. (…)

To maintain their performance, bankers pushed harder, trying to reassert control over their bodies, writes Michel: “One banker combated her eating disorder by fasting and exercising more, training for a marathon even after midnight.” Bankers sought distraction through compulsive shopping, partying and watching porn to counteract the numbness (‘‘I need something to feel passionate about”), to achieve control (‘‘These are all ways to control something’’), and to escape (‘‘It is a way to escape, so that I cannot even ruminate about my problems if I wanted to’’).

Addiction and self-flagellation went hand in hand. One banker said, ‘‘The only way I can keep myself up nights in a row is through a mix of caffeine pills and prescription meds.’’ She even ignored serious injuries to her body. ‘‘I fell on my way to a meeting,” she recalled for Michel. “The leg changed color and I had pain but I chose not to think about it until after the meeting.’’ Her leg was actually broken in two places. (…)

High-finance intervention specialists, like Curry, have seen an uptick in drug abuse on Wall Street since 2008. It’s not necessarily because these guys are stressed. Just the opposite: It’s because many of them are bored.

{ The Fix | Continue reading }

photo { Daniel Ribar }

Trash past death

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Several studies suggest that memories can be pharmaceutically dampened. For example, researchers recently showed that a drug called ZIP causes cocaine-addicted rats to forget the locations where they had regularly been receiving cocaine. Other drugs, already tested in humans, may ease the emotional pain associated with memories of traumatic events.

Many are alarmed by the prospect of pharmaceutical memory manipulation. In this brief comment, I argue that these fears are overblown. Thoughtful regulation may someday be appropriate, but excessive hand-wringing now over the ethics of tampering with memory could stall research into promising methods of preventing and treating post-traumatic stress.

{ SSRN | Continue reading }

photo { Nigel Shafran, Moonflower, 1990 }

From the fight with wild beasts returned he home

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Alexander Shulgin, the chemist who re-discovered MDMA (after it was synthesised and abandoned by Merck) and went on to discover hundreds of psychedelic drugs such as the 2C* family. He is famous not only for independently discovering and developing so many psychedelics but for testing them extensively on himself and for writing the core textbooks of the psychedelic literature, PiHKAL (‘Phenethylamines I Have Known and Loved’) and TiHKAL (‘Tryptamines I Have Known and Loved).

{ Neurobonkers | Continue reading }

You’ll worry less about what people think about you when you realize how seldom they do

Wallace had been taking Nardil for his depression since 1989. Nardil is a monoamine oxidase inhibitor, or MAOI, a member of the earliest generation of antidepressants; newer drugs are usually not only more effective against the illness but also less likely to cause collateral damage. In 2007 Wallace was a happy man, writing, married since 2004, for the first time, to the artist Karen Green, and teaching at Pomona College, one of the distinguished Claremont Colleges, where he had an endowed professorial chair that gave him pretty much free rein. After dinner at a Persian restaurant in Claremont one evening, he developed excruciating stomach pains that lasted several days. His doctor suspected a dire food interaction with Nardil, and suggested Wallace go off that outdated medication and try something newer. Wallace had already suspected for several months that Nardil was impeding the flow of The Pale King—though it evidently had not interfered with Infinite Jest—so the idea sounded promising. But then Wallace tried doing without any medication at all, and he landed in the hospital in the fall of 2007. After that he went on one drug after another but never really gave any of them the chance to be effective. Not wanting to foul his home, he tried suicide by overdose in a nearby motel, but survived. A course of twelve electroconvulsive treatments failed to work. He went back on Nardil; it did not kick in quickly enough. Not caring any more what he fouled, on September 12, 2008, he waited for his wife to leave for her gallery, wrote her a two-page note, and hanged himself on the patio of their Claremont home. He left a neat stack of manuscript pages in his garage office for his wife to find.

{ The Claremont Institute | Continue reading }

‘By three methods we may learn wisdom: First, by reflection, which is noblest; second, by imitation, which is easiest; and third, by experience, which is the bitterest.’ –Confucius

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The treatment of addiction and dependence on, and misuse of, alcohol and other drugs is one of the largest unmet needs in medicine today, so the development of new treatments is a pressing need. However, we have seen the development and use of different terminologies for different drug addictions, which confuses prescribers, users and regulators alike. Here we try to clarify terminology of treatment models based on the pharmacology of treatment agents. This editorial covers all drugs that are used for their pleasurable effects and which therefore can lead to harmful/hazardous use, dependence and addiction. These include nicotine, alcohol and abused prescription drugs such as benzodiazepines, as well as opioids and stimulants.

{ SAGE | Continue reading }

Fuck yeah, this broome is metal

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What’s the deal with witches and broomsticks? (…)

Harner notes that since antiquity many hallucinogenic plants have been known throughout the world, including some species of the potato family such as jimsonweed, devil’s-weed, mad apple, etc., as well as potato cousins like mandrake, henbane, and belladonna.

Trolling through the works of medieval and Renaissance writers, Harner finds a number of instances in which witchy hallucinations follow a potent hit of drugs. How were these drugs administered? Typically in the form of an ointment. Where was this ointment applied? To the skin, of course, but more effectively to the mucous membranes. Where can one find mucous membranes? In the vagina, among other places. How would one apply ointment to one’s vagina? Well, one can always count on one’s fingers, I suppose. But you could also use, uh, a pole. And where might one find a pole in the average peasant household? A broomstick.

Harner buttresses his thesis with some choice quotes. From a witchcraft investigation in 1324: “In rifleing the closet of the ladie, they found a Pipe of oyntment, wherewith she greased a staffe, upon the which she ambled and galloped through thick and thin.” Also this from around 1470: “But the vulgar believe, and the witches confess, that on certain days or nights they anoint a staff and ride on it to the appointed place or anoint themselves under the arms and in other hairy places.”

{ The Straight Dope | Continue reading }

Somewhere around Barstow

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Now I’m feelin the highs and ya feelin the lows, the beat starts gettin into your toes

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Everything we do is for the purpose of altering consciousness. We form friendships so that we can feel certain emotions, like love, and avoid others, like loneliness. We eat specific foods to enjoy their fleeting presence on our tongues. We read for the pleasure of thinking another person’s thoughts. Every waking moment—and even in our dreams—we struggle to direct the flow of sensation, emotion, and cognition toward states of consciousness that we value.

Drugs are another means toward this end. Some are illegal; some are stigmatized; some are dangerous—though, perversely, these sets only partially intersect. There are drugs of extraordinary power and utility, like psilocybin (the active compound in “magic mushrooms”) and lysergic acid diethylamide (LSD), which pose no apparent risk of addiction and are physically well-tolerated, and yet one can still be sent to prison for their use—while drugs like tobacco and alcohol, which have ruined countless lives, are enjoyed ad libitum in almost every society on earth. There are other points on this continuum—3,4-methylenedioxymethamphetamine (MDMA or “Ecstasy”) has remarkable therapeutic potential, but it is also susceptible to abuse, and it appears to be neurotoxic.

{ Sam Harris | Continue reading }

Green Goblin: Follow the cold shiver running down your spine…

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{ Life magazine, 1954 | more }

With the poison of a junkie’s broken promise on his lip

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It was 1985. I was 12 and standing next to my mother in a police station in Greenwich Village. She was a pretty red-haired gal in her late 30s, but the three police officers she was talking to weren’t looking at her. They were looking at the bag of crack vials she had in her hands, confused about what they were. I wasn’t confused. We had a lot of crack vials in our apartment at that point. Hundreds of them. My brothers and I played with them in Washington Square Park. We carried them around in our pockets the way other kids carried marbles.

I didn’t know then that this encounter would inspire a movement; that a group of local mothers would decide to do what the befuddled police would not: reclaim Washington Square Park from the drug dealers. (…)

My parents moved into our apartment at 32 Washington Square West in 1975. Over the next decade we watched as an army of dealers and their customers took over the heart of Greenwich Village. As a kid, I knew you didn’t ride your bicycle into the park, because a junkie would take it from you. The park’s arch, built as an imitation of the Arc de Triomphe, was covered in graffiti. When the city painted over it in 1981, Mayor Ed Koch applied the last stroke of white paint, then remarked, “That’ll last about an hour.”

{ John Carney/NY Times | Continue reading }

artwork { Kathe Kollwitz, Death and a Woman Struggling for a Child, 1911 }

I get high, high, high. Everyday. I get high, high, high. Every night.

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Synthetic drugs that use legal compounds but mimic the highs of everything from marijuana to cocaine are proliferating among do-it-yourself pharma labs across the country. Bad trips—and fatal side effects—are increasing, too.

{ BusinessWeek | Continue reading }

bonus:

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‘Everything in life is somewhere else, and you get there in a car.’ —E. B. White

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Friday, August 12, 1988. On the sidewalk outside 57 Great Jones Street, the usual sad lineup of crack addicts slept in the burning sun. (…) In the months before his death, Basquiat claimed he was doing up to a hundred bags of heroin a day.

{ NY Times | Continue reading }

images { Odette England }

I’ve been dodging bullets since I was fourteen. No one can kill me. I’m fucking blessed.

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Danish researchers attempted to establish standard mortality ratios for the drugs cannabis, cocaine, amphetamine, MDMA (ecstasy) and opioids (e.g. heroin). (…)

In brief, the results showed the following: (…)

3. Pot smokers showed 5x increase in mortality rates (compared to the general population). (…)

4. Cocaine and amphetamine users showed 6x death rates of the general population. (…)

5. Opiod users show increased mortality rates. Findings for both stimulants and opioids are in accordance with studies from other countries. Users of Heroin and other opioids showed by far the highest mortality rates of all drugs of abuse.

6. Ecstasy (MDMA) users did not show increased mortality rates.

{ Neuropoly | Continue reading }

screenshot { Harvey Keitel in Abel Ferrara’s Bad Lieutenant, 1992 )

Dr. Frederick Frankenstein: You played that music in the middle of the night… Frau Blücher: Yes. Dr. Frederick Frankenstein: …to get us to the laboratory.

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A spectacular case of psychosis, rather oddly described as ‘Methamphetamine Induced Synesthesia’, in a case report just published in The American Journal on Addictions.

The report concerns a 30-year-old gentleman from the Iranian city of Shiraz with a long-standing history of drug use who recently started smoking crystal:

Six months PTA [prior to admission] (October 2009), he started smoking methamphetamine once a day, and gradually increased the frequency to three times a day.

Two months PTA (January 2010), he developed symptoms of auditory and visual hallucinations (seeing fairies around him that talked to him and forced him to conduct aggressive behavior), self-injury, and suicidal attempts.

He developed odd behaviors such as boiling animal statues. He was hearing the voices of colors, which were in the carpet. Colors moved around and talked to each other about the patient. He also saw the heads of different kinds of animals gathering on a board, and they talked to him.

Finally, his mother brought him to the emergency room of Ebnecina Psychiatric Hospital in Shiraz.

{ Mind Hacks | Continue reading }

artwork { James Marshall }

Yes I think he made them a bit firmer sucking them like that so long he made me thirsty titties

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Anecdotal reports suggest that some users of ecstasy (MDMA) experience increased feelings of empathy and are more social while under influence of the drug. Such effects may contribute to the timing and frequency of ecstasy use and may also contribute to risk of abuse or dependence. Understanding this phenomenon in more detail might provide clinicians with better strategies to reduce use and the associated complications of ecstasy use.

Studying acute effects of illicit drugs is difficult under natural conditions. Users of ecstasy commonly also use alcohol, nictoine and other illicit drugs in the context of ecstasy use. Isolating psychological effects of one agent in this type of environment is difficult if not impossible. One alternative is to admiinster ecstasy in a laboratory setting with subjects blind to whether ecstasy or placebo is being administered. However, this approach poses significant ethical challenges. One approach, is to limit human study in the lab to those who have previously use ecstasy and intend to continue using. (…)

A study in Biological Psychiatry took this approach when over four sessions, healthy ecstasy using volunteers received either a low or high dose of MDMA, a dose of methamphetamine (METH) or placebo. (…)

Findings suggest MDMA increases social approach (sociability). The study supports the possibility that increased social behavior with MDMA might be due to a reduced sensitivity to negative emotions of others rather than increasing recognition of positive emotions in others.

{ Brain Posts | Continue reading }

photo { Noritoshi Hirakawa }

Is there any… no trouble I hope? I see you’re…

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Why is aspirin toxic to cats?

One animal’s cure can be another animal’s poison. Take aspirin – it’s one of the most popular drugs on the market and we readily use it as a painkiller. But cats are extremely sensitive to aspirin, and even a single extra-strength pill can trigger a fatal overdose. Vets will sometimes prescribe aspirin to cats but only under very controlled doses.

The problem is that cats can’t break down the drug effectively. They take a long time to clear it from their bodies, so it’s easy for them to build up harmful concentrations. This defect is unusual – humans clearly don’t suffer from it, and neither do dogs. All cats, however, seem to share the same problem, from house tabbies to African lions.

{ Discover | Continue reading }

The term big cat – which is not a biological classification – is used informally to distinguish the larger felid species from smaller ones. One definition of “big cat” includes the four members of the genus Panthera: the tiger, lion, jaguar, and leopard. Members of this genus are the only cats able to roar. A more expansive definition of “big cat” also includes the cheetah, snow leopard, clouded leopard, and cougar.

{ Wikipedia | Continue reading }

A mental block. And a sense of duty. And a fear.

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Jeannie asks, “Why are you here?” and Charlie, dead-panned, replies, without regret: “Drugs.” And then he slowly disarms her bitchiness with his outrageously sexy insouciance, transforming her annoyance into delight (they end up making out).

That’s when we first really noticed Charlie Sheen, and it’s the key moment in his movie career (it now seems to define and sum up everything that followed). He hasn’t been as entertaining since. Until now. In getting himself fired from Two and a Half Men, this privileged child of the media’s sprawling entertainment Empire has now become its most gifted prankster. And now Sheen has embraced the post-Empire, making his bid to explain to all of us what celebrity means in that world. Whether you like it or not is beside the point. It’s where we are, babe. We’re learning something. (…)

Post-Empire isn’t just about admitting doing “illicit” things publicly and coming clean—it’s a (for now) radical attitude that says the Empire lie doesn’t exist anymore, you friggin’ Empire trolls. To Empire gatekeepers, Charlie Sheen seems dangerous and in need of help because he’s destroying (and confirming) illusions about the nature of celebrity. He’s always been a role model for a certain kind of male fantasy. Degrading, perhaps, but aren’t most male fantasies? (I don’t know any straight men who fantasize about Tom Cruise’s personal life.) Sheen has always been a bad boy, which is part of his appeal—to men and women. There’s a manly mock-dignity about Sheen that both sexes like a lot. What Sheen has exemplified and has clarified is the moment in the culture when not giving a fuck about what the public thinks about you or your personal life is what matters most—and what makes the public love you even more (if not exactly CBS or the creator of the show that has made you so wealthy). It’s a different brand of narcissism than Empire narcissism.

{ Bret Easton Ellis | Continue reading }

‘Anything that gets the adrenalin moving like a 440 volt blast in a copper bathtub is good for the reflexes and keeps the veins free of cholesterol.’ –Hunter S. Thompson

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Forty years ago, on March 21, 1971, Hunter S. Thompson and a Chicano activist attorney named Oscar Zeta Acosta drove from Los Angeles to Las Vegas to talk over an article Thompson was writing about the barrios of East L.A. When the account of their journey appeared in Rolling Stone in November of that year, Thompson and Acosta had morphed into Raoul Duke and his 300-pound Samoan attorney and the trunk of their car, the Great Red Shark, had become a rolling drug dispensary. (…)

Fear and Loathing compresses two separate trips Thompson took to Las Vegas that spring – the first to cover a motorcycle race called the Mint 400, the second to cover the National District Attorneys’ Conference on Drug Abuse – into a single hellish week of drug consumption and debauchery.

{ The Millions | Continue reading }

On 29 April 1971, Thompson began writing the full manuscript in a hotel room in Arcadia, California, in his spare time. (…)

In November 1971, Rolling Stone published the combined texts of the trips as Fear and Loathing in Las Vegas: A Savage Journey to the Heart of the American Dream as a two-part article illustrated by Ralph Steadman. (…)

The New York Times said it is “by far the best book yet on the decade of dope.”

{ Wikipedia | Continue reading }

photo { Thompson and Acosta, 1971 }

Maybe it’s not dope. Maybe it’s booze, maybe it’s glue, maybe it’s gasoline. Maybe it’s a gunshot to the head. But something. Something to relieve the pressures of their everyday life, like having to tie their shoes.

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How do you distill the past 40 years addiction research into ten essential messages? (…)

1. Addiction is fundamentally about compulsive behavior
In normal behaviors, the control in our brains is top down. In addiction the cortex (the decision making bit of the brain) becomes ‘eroded’ to a ‘dehumanised’ compulsion.

(…)

2. Compulsive drug seeking starts outside conscious thought

(…)

3. Addiction is about 50% inherited, but it’s much more complicated than that…


(…)

4. 75-90% of those asking for help from services have diagnosable mental health problems including depression, social phobia and post traumatic stress disorder.

(…)

5. Addiction is a chronic relapsing disorder in the majority


(…)

6. Different therapies appear to produce similar treatment outcomes 


(…)

7. “Come back when you are motivated” is no longer an acceptable therapeutic response


(…)

10. Change takes time


{ Binge Inking | Continue reading }

screenshot { The Naked Gun, 1988 }



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