We are in the business of making mistakes. The only difference between the winners and the losers is that the winners make small mistakes.
The kings of the Spanish Habsburg dynasty (1516–1700) frequently married close relatives in such a way that uncle-niece, first cousins and other consanguineous unions were prevalent in that dynasty. In the historical literature, it has been suggested that inbreeding was a major cause responsible for the extinction of the dynasty when the king Charles II, physically and mentally disabled, died in 1700 and no children were born from his two marriages, but this hypothesis has not been examined from a genetic perspective. In this article, this hypothesis is checked by computing the inbreeding coefficient (F) of the Spanish Habsburg kings from an extended pedigree up to 16 generations in depth and involving more than 3,000 individuals. […]
It is speculated that the simultaneous occurrence in Charles II of two different genetic disorders […] could explain most of the complex clinical profile of this king, including his impotence/infertility which in last instance led to the extinction of the dynasty.
{ PLoS | Continue reading | Read more: Nature }
photo { Erich Heckel, Fränzi Reclining, 1910 }
